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Overview

Capsule endoscopy is a non-invasive procedure that uses a swallowable, pill-sized camera to capture images from inside the digestive tract. It is primarily used to examine the small bowel, which can be difficult to assess completely with standard upper GI endoscopy or colonoscopy.

The capsule records images but cannot take a biopsy or provide treatment. If an abnormality is identified, another endoscopic, radiological or surgical procedure may be needed for tissue sampling or treatment.

Capsule Endoscopy
How the Technology Works
Capsule endoscopy records thousands of images as a small camera travels naturally through the digestive tract.
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Camera Capsule
The capsule contains a miniature camera, light source, battery and transmitter. Once swallowed, it moves through the digestive tract through normal intestinal contractions while capturing images of the bowel lining.
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Image Transmission
Sensors attached to the abdomen or a sensor belt receive the images transmitted by the capsule. The images are stored on a portable recorder worn during the examination, allowing most people to continue with light daily activities.
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Specialist Image Review
After the recording period, the sensors and recorder are returned to the healthcare facility. Specialist software arranges the images into a video, which is reviewed by a trained clinician for bleeding, polyps, masses, narrowing or other abnormalities.

Role in Cancer Care

Investigating Unexplained Bleeding
Capsule endoscopy may be recommended when gastrointestinal bleeding or iron-deficiency anemia remains unexplained after upper GI endoscopy and colonoscopy. It can identify bleeding sites or abnormalities within the small bowel that may not be reached by these procedures. Potential causes include ulcers, abnormal blood vessels, inflammation, polyps and tumours.
Investigating Unexplained Bleeding
Detecting Small-Bowel Tumours
The capsule can identify masses, polyps, ulcerated areas or narrowing that may suggest a small-bowel tumour. It may contribute to the evaluation of adenocarcinomas, neuroendocrine tumours, gastrointestinal stromal tumours, lymphomas and other lesions affecting the small bowel. The images alone cannot confirm the type of cancer, and tissue sampling is usually required.
Detecting Small-Bowel Tumours
Assessing Polyposis Syndromes
Capsule endoscopy may be used in selected people with inherited conditions that increase the risk of small-bowel polyps or cancer, such as Peutz–Jeghers syndrome or familial adenomatous polyposis. It can help identify the number, approximate size and location of polyps beyond the reach of standard endoscopy. The findings may guide surveillance or the need for removal through another procedure.
Assessing Polyposis Syndromes
Evaluating Symptoms and Imaging Findings
The procedure may help investigate persistent abdominal pain, unexplained weight loss or an abnormality identified on CT, MRI or another test. It is usually considered after more common causes have been assessed and when the clinical team believes examination of the small-bowel lining may add useful information. Not every symptom or scan abnormality is suitable for capsule endoscopy.
Evaluating Symptoms and Imaging Findings
Guiding Further Investigation
Images from capsule endoscopy can help determine where additional testing or treatment should be directed. Depending on the findings, the next step may include device-assisted enteroscopy, CT or MR enterography, biopsy or surgery. The capsule’s estimate of an abnormality’s location is useful but may not always be exact.
Guiding Further Investigation
Supporting Follow-Up
In selected patients, capsule endoscopy may be used to monitor known small-bowel polyps or reassess the bowel after earlier findings. It can also help investigate new bleeding or anemia during or after cancer treatment. The decision to repeat the examination depends on the underlying condition, previous findings and the information required.
Supporting Follow-Up

What to Expect

Before the Test 

You will receive instructions about diet, bowel preparation and when to stop eating and drinking. A laxative preparation may be prescribed to clear the bowel and improve the quality of the images.

Tell the clinical team about:

  • Difficulty swallowing or a history of choking

  • Previous bowel obstruction, narrowing or abdominal surgery

  • Crohn’s disease or other conditions that may narrow the bowel

  • All medicines and supplements you take, including iron tablets

  • Diabetes or medicines that may need adjustment while fasting

  • A pacemaker, defibrillator or another implanted electronic device

  • Pregnancy or the possibility of pregnancy

Do not stop or change prescribed medicines unless instructed. If narrowing or obstruction is suspected, imaging or a dissolvable patency capsule may be recommended first to check whether a capsule can pass safely through the bowel.

Before the Test

During the Test

Sensors will be attached to the abdomen or you will wear a sensor belt connected to a portable recorder. You will then swallow the capsule with water; sedation and anesthesia are not normally required.

You will receive instructions about when you may drink, eat and take medicines after swallowing the capsule. Avoid strenuous exercise, bending repeatedly or removing the equipment during the recording period. The examination usually records images for approximately 8–12 hours, depending on the capsule system and clinical protocol.

The capsule moves naturally through the digestive tract, and most people do not feel it. You do not usually need to remain at the healthcare facility throughout the recording period unless your clinical team advises otherwise.

During the Test

After the Test

At the end of the recording period, the sensor belt or abdominal sensors and recorder are removed or returned as instructed. The disposable capsule normally passes naturally in a bowel movement, often without being noticed, and should not be retrieved unless specifically requested.

Do not undergo an MRI scan until the capsule has passed or your clinical team has confirmed that it is no longer inside your body. MRI exposure while a capsule remains in the digestive tract could cause injury.

Contact the clinical team promptly if the capsule has not been seen to pass within the period they specify. Seek urgent medical attention if you develop:

  • Increasing or severe abdominal pain

  • Persistent vomiting

  • Marked abdominal swelling

  • Inability to pass stool or gas

  • Fever or rapidly worsening symptoms

The recorded images require detailed specialist review, so results are not usually available immediately. Your clinical team will explain the findings and whether another investigation, biopsy or treatment is required.

After the Test

Potential Benefits

Capsule endoscopy may provide several benefits when evaluating suspected or confirmed cancer:
  • Cancer prevention: Precancerous polyps can be identified and removed.
  • Early detection: Colorectal cancer may be detected before it causes symptoms.
  • Direct visualisation: The lining of the rectum and colon can be examined in real time.
  • Tissue diagnosis: Biopsies can be taken directly from suspicious areas.
  • Polyp removal: Many polyps can be removed during the examination.
  • Accurate localisation: The location of a tumour or lesion can be documented or marked for treatment.
  • Diagnostic and therapeutic use: Bleeding, selected early lesions or obstruction may be treated endoscopically in suitable patients.
  • Surveillance: The colon can be monitored after polyp removal or colorectal cancer treatment.
Capsule Endoscopy
Frequently Asked Questions
01 Is capsule endoscopy painful?
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The procedure is generally painless, and most people do not feel the capsule moving through the digestive tract. Swallowing it is similar to swallowing a large tablet. Tell the clinical team beforehand if you have difficulty swallowing, as assisted placement of the capsule may be considered.
02 Can capsule endoscopy take a biopsy?
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No. The capsule can photograph abnormal areas but cannot collect tissue, remove a polyp or provide treatment. If the images show a suspicious lesion, device-assisted enteroscopy, surgery or another procedure may be required to obtain a biopsy.
03 Can the capsule become stuck?
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Capsule retention is uncommon but can occur if the bowel is narrowed by a tumour, inflammation, scar tissue or another condition. A retained capsule may not cause symptoms, but medication, endoscopy or surgery may occasionally be needed to remove it. Imaging or a dissolvable patency capsule may be used beforehand when an increased risk of retention is suspected.
04 What is a patency capsule?
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A patency capsule is a dissolvable test capsule used to assess whether the digestive tract is open enough for a video capsule to pass. If it becomes held within a narrowed area, it is designed to break down over time. Its passage can help the clinical team decide whether standard capsule endoscopy is appropriate.
05 Can capsule endoscopy rule out cancer?
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A normal examination can be reassuring, but capsule endoscopy cannot exclude every cancer. The capsule may move too quickly, an abnormality may be hidden by bowel contents or some areas may not be clearly recorded. Further investigation may still be recommended when symptoms, imaging or other test results remain concerning.
06 What happens if an abnormality is found?
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The next step depends on the appearance, size and estimated location of the abnormality. The clinical team may recommend device-assisted enteroscopy for biopsy, cross-sectional imaging such as CT or MRI, repeat endoscopy or surgical evaluation. A diagnosis of cancer is generally confirmed through examination of a tissue sample rather than capsule images alone.
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